Pilot Study to Evaluate the Efficacy of Polynucleotide Sodium Compared to Sodium Hyaluronate and Crosslinked Sodium Hyaluronate in Patients with Knee Osteoarthritis.
We engaged in a pilot study comparing the effectiveness of polynucleotide sodium with sodium hyaluronate for knee osteoarthritis pain relief. With 15 patients divided into three groups, all received ultrasound-guided injections over three weeks.
Our findings showed that those treated with polynucleotide sodium experienced a significant reduction in weight-bearing pain compared to the hyaluronic acid group after six weeks. However, the other measures of pain and quality of life did not exhibit notable differences between the groups.
Overall, polynucleotide sodium proved more effective in alleviating weight-bearing pain in this limited study.
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Most Useful Reviews
9
Significant improvement
698 people found this helpful
After completing a course of collagen, I've noticed a marked improvement in my joints. Previously, I struggled with discomfort and bone pain, especially in my knees. However, after a month of taking this product, the pain has significantly decreased, often disappearing entirely. On days when the pain returns, it's far less intense than before, which is a relief.
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9
Aching pains vanish
215 people found this helpful
I found the second type of collagen very effective for my joint pain. Previously, I suffered from bone pain in my knees, but after completing the course, the pain has vanished entirely.
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7.5
Noticeable improvements
118 people found this helpful
I've been using collagen type 2 for joint pain, especially for aching knees and hands. Improvements were noticeable after a couple of weeks of consistent use, making this collagen cycle truly beneficial for my condition.
Pilot Study to Evaluate the Efficacy of Polynucleotide Sodium Compared to Sodium Hyaluronate and Crosslinked Sodium Hyaluronate in Patients with Knee Osteoarthritis.
We engaged in a pilot study comparing the effectiveness of polynucleotide sodium with sodium hyaluronate for knee osteoarthritis pain relief. With 15 patients divided into three groups, all received ultrasound-guided injections over three weeks.
Our findings showed that those treated with polynucleotide sodium experienced a significant reduction in weight-bearing pain compared to the hyaluronic acid group after six weeks. However, the other measures of pain and quality of life did not exhibit notable differences between the groups.
Overall, polynucleotide sodium proved more effective in alleviating weight-bearing pain in this limited study.
Read More
User Reviews
USERS' SCORE
Good
Based on 90 Reviews
8.5
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Negative Reviews
9
Significant improvement
698 people found this helpful
After completing a course of collagen, I've noticed a marked improvement in my joints. Previously, I struggled with discomfort and bone pain, especially in my knees. However, after a month of taking this product, the pain has significantly decreased, often disappearing entirely. On days when the pain returns, it's far less intense than before, which is a relief.
Read More
9
Aching pains vanish
215 people found this helpful
I found the second type of collagen very effective for my joint pain. Previously, I suffered from bone pain in my knees, but after completing the course, the pain has vanished entirely.
Read More
7.5
Noticeable improvements
118 people found this helpful
I've been using collagen type 2 for joint pain, especially for aching knees and hands. Improvements were noticeable after a couple of weeks of consistent use, making this collagen cycle truly beneficial for my condition.
Read More
10
Complete pain relief
57 people found this helpful
My knees and shoulders ached so much that exercising became challenging. After starting this collagen with vitamin C, I experienced noticeable relief from bone pain. Within 4 days it had improved, and after 1.5 months, I hardly recalled the pain at all.
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9
Pains go away
50 people found this helpful
Using this product has greatly improved my joint health and well-being. Over time, I noticed that the bone pain I once experienced had subsided significantly, making daily activities much easier.
Bone pain is a discomfort or ache that originates within the bones themselves and can range from mild to severe. It is different from muscle or joint pain, as it directly affects the skeletal structure. Bone pain can be caused by a variety of factors, including injuries, medical conditions such as osteoarthritis or osteoporosis, infections, or tumors. Symptoms may vary depending on the underlying cause but often include a dull, penetrating ache that may worsen with movement or pressure.
If you're experiencing persistent bone pain, it’s essential to consult with a healthcare professional for a proper diagnosis and treatment plan. Imaging tests like X-rays, MRI, or CT scans may be utilized to determine the root cause of the pain. Treatment can vary widely, ranging from medications to alleviate pain and inflammation to physical therapy or, in some cases, surgical interventions. Understanding the underlying cause is crucial to effectively managing bone pain and ensuring the best path to recovery.
Collagen supplements are dietary products designed to enhance the levels of collagen in your body, a vital protein that plays an essential role in maintaining skin elasticity, joint health, and overall structural integrity. Collagen is naturally found in connective tissues, skin, tendons, and cartilage, but as we age, our body's natural production of collagen diminishes. This decline can lead to signs of aging, such as wrinkles and joint discomfort. Collagen supplements often come in various forms, including powders, capsules, and liquids, derived from animal sources like bovine or marine collagen.
Many people take collagen supplements with the hope of improving skin hydration, reducing the appearance of wrinkles, and supporting joint health. Some studies suggest that collagen supplementation may help increase skin elasticity, improve hydration levels, and potentially reduce joint pain associated with conditions like osteoarthritis. However, it's important to remember that while some users report positive effects, individual results can vary and more research is needed to fully understand the benefits and optimal dosages. As always, it's a good idea to consult with a healthcare professional before starting any new supplement regimen.
Collagen supplements have gained attention for their potential benefits in joint and bone health, but their effectiveness in specifically addressing bone pain requires further exploration. Collagen is a protein that plays a vital role in the structure and strength of various tissues, including cartilage and bones. Some studies suggest that collagen peptides may help improve the condition of cartilage in joints, which can indirectly alleviate discomfort associated with bone and joint pain. This is particularly relevant for individuals with conditions like osteoarthritis, where cartilage breakdown leads to increased pain and inflammation.
While the evidence surrounding collagen supplements is promising, it's essential to approach these findings with caution. It's not universally accepted that collagen supplements can directly reduce bone pain, as individual results can vary. Additionally, many factors contribute to bone health, including diet, exercise, and underlying medical conditions. If you’re considering collagen supplements for bone pain relief, consult a healthcare professional to discuss your specific needs and the best approaches for managing your pain.
Based on user reviews, the timeline for seeing results from collagen supplements for bone pain varies, but many users report significant improvements within a few weeks to a month of consistent use. For instance, one user highlighted a marked decrease in knee pain after just a month of taking collagen, emphasizing that the discomfort often disappeared Read Review. Another shared their relief from joint pain within only a week of starting the supplement Read Review.
Additional user experiences suggest that more pronounced benefits can emerge around the two to three-week mark. One user noted that their pain had vanished entirely after three weeks, while another reported less pain after a couple of weeks of use (review id='45e6f51b-8b4a-46ad-9ded-b597f4bcbc21' and review id='91388b76-eb3a-4637-b15e-fda49ff27503'). Therefore, if you're considering collagen for bone pain, you can anticipate potential improvements in the first few weeks, with ongoing benefits over a longer period of use.
The research on polynucleotide sodium suggests it may offer some benefit for individuals experiencing knee pain associated with osteoarthritis. A pilot study demonstrated that those who received injections of polynucleotide sodium reported a significant reduction in weight-bearing pain compared to those who were treated with hyaluronic acid, highlighting its potential as a pain relief option for certain conditions [1]. However, it's essential to note that this study focused specifically on knee pain, and the results may not necessarily translate to other types of bone pain or broader applications.
Based on user reviews, many individuals have reported significant improvements in their joint and bone pain after using collagen supplements. For instance, one user noted that after a month of supplementation, the pain in their knees had substantially decreased, often disappearing entirely, leading to greater ease in daily activities Read Review. Another user expressed similar sentiments, stating that their knee pain vanished completely after a course of collagen, illustrating the potential efficacy of the product for alleviating bone pain Read Review.
Moreover, several users reported improvements within just a few days to weeks, with one user experiencing relief from discomfort in their knees and shoulders just four days after beginning the collagen regimen Read Review. Another shared their success after a month, indicating a remarkable difference in their knee pain and the overall quality of movement Read Review. However, it's important to note that results can vary from person to person, and while many users saw great improvements, individual experiences may differ depending on various factors such as pre-existing conditions, dosage, and consistent use.
Users have reported positive experiences when combining collagen supplements with other ingredients to alleviate bone pain. For instance, one user noted significant relief after taking collagen along with vitamin C, experiencing noticeable improvement in their knees and shoulders in just four days Read Review. Additionally, another reviewer highlighted the effectiveness of combining type 2 collagen with glucosamine, observing a marked reduction in joint pains and enhanced ease in climbing stairs Read Review. Such combinations appear to enhance the overall effectiveness of the supplement in managing bone-related discomfort.
Moreover, many users acknowledge that integrating these supplements into their regimen not only accelerates pain relief but also improves mobility. One review mentioned that, after weeks of consistent use of collagen alongside chondroitin, joint pains nearly vanished Read Review. Another user experienced incredible relief after taking collagen following a chondroitin course, attributing the quick reduction of bone pain to the combined approach Read Review. Overall, these user insights reflect a favorable view of supplement combinations for efficiently managing bone pain.
Based on user reviews, many individuals have reported positive outcomes from collagen supplements, specifically for bone pain. Several users emphasized that after taking collagen, particularly type 2, they experienced significant relief from joint pain, especially in the knees and shoulders. For instance, one user noted complete pain disappearance within a month of consistent usage (Read Review), while another user reported substantial improvement in mobility and joint discomfort after just a few days of taking the supplement (Read Review).
The dosage seems to vary, but a common theme among reviews is the effectiveness of a regimen that includes taking 2 to 3 capsules daily, often alongside other supplements like glucosamine or vitamin C (Read Review; Read Review). Users highlighted that they began noticing improvements in joint health often within a few weeks, and recommended maintaining this dosage for ongoing benefits (Read Review). Overall, many users confidently advocate for incorporating collagen into their routines as a reliable approach to managing bone and joint pain.
9
Significant improvement
698 people found this helpful
After completing a course of collagen, I've noticed a marked improvement in my joints. Previously, I struggled with discomfort and bone pain, especially in my knees. However, after a month of taking this product, the pain has significantly decreased, often disappearing entirely. On days when the pain returns, it's far less intense than before, which is a relief.
9
Knee pain disappeared
5 people found this helpful
The product is quite effective! I was advised to take it for my knee joint pain, and after a week of using it, the pain vanished.
9
Aching pains vanish
215 people found this helpful
I found the second type of collagen very effective for my joint pain. Previously, I suffered from bone pain in my knees, but after completing the course, the pain has vanished entirely.
10
Complete pain relief
57 people found this helpful
My knees and shoulders ached so much that exercising became challenging. After starting this collagen with vitamin C, I experienced noticeable relief from bone pain. Within 4 days it had improved, and after 1.5 months, I hardly recalled the pain at all.
9
Joint pain reduction
2 people found this helpful
I have suffered from joint pain and crunching knees, which intensified with exertion. Having taken joint support complexes before, I've usually noted some improvement. After a month on this supplement, the difference was remarkable. My knees, particularly, appreciated this collagen. After completing the course, the pain in my knees has significantly decreased, with even days of complete relief. If it does return, it’s nothing like it was before. If you find this review helpful, please click Yes. Thank you!
9
Joint pain reduced
3 people found this helpful
Using this in combination with chondroitin and glucosamine has yielded excellent results—my joint pains are nearly gone. Climbing stairs has become much easier, and I plan to repeat this course.
9
Pain relief noted
16 people found this helpful
This collagen has truly saved my knee! Despite my age, I have been struggling with joint issues, especially in my knee, which caused significant bone pain. Thankfully, I ordered this product beforehand as suggested by a colleague, to take after a chondroitin course. Within two days, the pain was significantly reduced, and after five days, it entirely vanished. Even my father's condition improved after a week of taking it, and now we plan to continue this in the autumn and spring. I can recommend it wholeheartedly.
7.5
Improved knee pain
6 people found this helpful
I used these supplements for my knee bone pain, and it has improved significantly. It's wonderful, and I highly recommend it. I take 2-3 tablets every day and break my fast an hour later.
9
Joint pain relief
23 people found this helpful
After adopting this collagen for my joints, having lived with hypothyroidism and suffering from bone pain, I've experienced incredible relief. My joints no longer crack, and there's a noticeable reduction in discomfort during movements.
8
Polynucleotide sodium reduces knee pain
Pilot Study to Evaluate the Efficacy of Polynucleotide Sodium Compared to Sodium Hyaluronate and Crosslinked Sodium Hyaluronate in Patients with Knee Osteoarthritis.
We engaged in a pilot study comparing the effectiveness of polynucleotide sodium with sodium hyaluronate for knee osteoarthritis pain relief. With 15 patients divided into three groups, all received ultrasound-guided injections over three weeks.
Our findings showed that those treated with polynucleotide sodium experienced a significant reduction in weight-bearing pain compared to the hyaluronic acid group after six weeks. However, the other measures of pain and quality of life did not exhibit notable differences between the groups.
Overall, polynucleotide sodium proved more effective in alleviating weight-bearing pain in this limited study.
References
Kim JY, Kim YN, Lee YJ, Sim SE, Ko YR, et al. Pilot Study to Evaluate the Efficacy of Polynucleotide Sodium Compared to Sodium Hyaluronate and Crosslinked Sodium Hyaluronate in Patients with Knee Osteoarthritis. J Clin Med. 2021;10. doi:10.3390/jcm10051138